Open Access Journal of Biomedical Science | Biomedscis

Teaching and Learning Activities in Critical Care: Resident’s Perspective in a Developing Country by Ayesha Aleem Qureshi* in Open Access Journal of Biomedical Science (OAJBS) Background: the need for critical care services has increased tremendously specially after the current coronavirus disease 2019 pandemic. It has flounced whole world, posing a high pressure on critical care unit due to large number of patients needing critical care. Although the resources are already reduced due to lack of awareness and less recognized fellowship units in critical care. The dire need has raised concerns over training of residents in critical care especially in Pakistan. The rationale of this study is to improve the training of critical care residents by focusing on the teaching and learning activities and behaviors of teaching physicians which greatly impact the residents in critical care departments. No studies addressing this area have been reported in Pakistan. Method: The study was cond...

Feasibility of “Hourglass-Pattern” Fascia Iliac Combined with Sacral Plexus Block in Elderly Femoral Neck Fractured Patients Undergoing Closed Reduction and Internal Fixation for Femoral Neck Fractures: A Prospective Observational Study by Huiyue Wang* in Open Access Journal of Biomedical Science (OAJBS) Background: To evaluate the feasibility of “hourglass-sign” fascia iliac block and sacral plexus block for elderly femoral neck fractured patients with multiple complications.  Methods: A total of 32 patients with femoral neck fracture undergoing closed reduction and internal fixation for femoral neck fractures were included. Ultrasound-guided “hourglass-sign” fascia iliac block and sacral plexus block anesthesia were applied to all patients. The success rate of anesthesia, the hemodynamic parameters, VAS scores, general clinical data and perioperative information would be collected. Results: 30 patients were included and analyzed into the study finally, all patients were diagnosed...

Immune Checkpoint Inhibitors for Esophageal Cancer by Shun Yamamoto* in Open Access Journal of Biomedical Science (OAJBS) Esophageal cancer (EC) is the seventh most common cancer, and patients with advanced EC have a poor prognosis. Recently, nivolumab and pembrolizumab, two immune checkpoint inhibitors (ICIs) that inhibit programmed cell death protein 1, have begun to be used for the treatment of advanced esophageal squamous cell carcinoma (ESCC). Based on the ATTRACTION-3 and KEYNOTE-181 trials, the use of nivolumab and pembrolizumab (only in programmed cell death ligand 1-positive cases) was approved for treatment by the US Federal Drug Administration for the treatment of patients with advanced ESCC. In addition, the CheckMate-577 and the KEYNOTE-590 trials have shown survival benefits for postoperative nivolumab in patients with resectable EC and for first line pembrolizumab plus doublet chemotherapy in patients with advanced EC, respectively. Many trials to evaluate ICI-containi...

The Deep Lymphatic Anatomy of the Foot by Wei Ren Pan* in Open Access Journal of Biomedical Science (OAJBS) Background:  Detail of the deep lymphatic anatomy of the foot remains the least described in medical literature. Methods:  Eight feet were harvested from four unembalmed human cadavers amputating above the ankle. A small amount of 6% hydrogen peroxide was used to find the deep lymphatic vessels around the dorsal and plantar metatarsal vessels. A fine needle was inserted into vessels and injected with a barium sulphate compound. Each specimen was dissected, photographed, and radiographed to demonstrate the deep lymphatic distribution of the foot. Results:  Deep collecting lymph vessels of the foot were found in the deep tissue of the dorsal and sole of the foot, they were: Dorsal metatarsal lymph vessel (DMLV); Lateral tarsal lymph vessel (LTLV); Central tarsal lymph vessel (CTLV); Medial tarsal lymph vessel (MTLV); Dorsalis pedis lymph vessel (DPLV); Anterior lat...