Facile Synthesis of Chitosan Nanoparticle with Different Features and Histopathological Ultrastructural Study on The Effect of Its Bio-complex with Bovine Serum Albumin: OAJBS Publishers
Facile Synthesis of Chitosan Nanoparticle with Different Features and Histopathological Ultrastructural Study on The Effect of Its Bio-complex with Bovine Serum Albumin in Mice Liver by Maged El-Kemary* in Open Access Journal of Biomedical Science (OAJBS) We have synthesized chitosan nanoparticles (CS-NPs) with different characteristics using ionic gelation method. Results showed that the synthesized CS-NPs with different concentrations of trisodium polyphosphate (TPP) are irregular – spherical shaped with narrow size distribution and high stability. The microporous chitosan was also synthesized with new features characterized with different techniques as SEM, EDX, FTIR and BET. The synthesized microporous chitosan has a surface area and pore volume of 245.571m 2 /g and 0.155cm 3 /g respectively. Its microporous surface is functionalized with carboxyl and amine groups. Histopathological and ultrastructural studies of mice liver were performed using optical and scanning electron micro