Osteoarthritis Linked to Diabetes Characterized Sharp Decreasing in Ser/Proline/Plcγ2 with Increasing Plcγ1, where Inhibiting S6K/BTK / Plcγ2 Affect TXA2 Synthesis Cause C-Lymphocytic Leukemia: OAJBS Publishers

Osteoarthritis Linked to Diabetes Characterized Sharp Decreasing in Ser/Proline/Plcγ2 with Increasing Plcγ1, where Inhibiting S6K/BTK / Plcγ2 Affect TXA2 Synthesis Cause C-Lymphocytic Leukemia by Ashraf Marzouk El Tantawi* in Open Access Journal of Biomedical Science (OAJBS)

Proper S6K /BTK and PLCγ2 are main regulations for thromboxane-A synthesis, and necessary for B-cell maturations and T-cells modulations and functions. The main factors that cause the Osteoarthritis “OA” and diabetes and linked between them are the deficiency of Ser amino acids and decreasing or down regulations of Ser phosphorylation signalling pathway which necessary for proper S6K productions, where normally the Ser phosphorylation signalling pathway is the basis of Ser /Thr phosphorylation signalling which normally necessary for proper Akt, S6K1 synthesis and necessary for RORs and IFNs synthesis and also necessary for running proper BTK and proper PLCγ2 productions , where S6K is main regulator for ATPase and for proper PLCγ1 and for PLCγ2 synthesis which necessary for bone growth and for increasing and modulating immune efficiency. Osteoarthritis “OA” is characterized by a sharp expression in Gamma-Phospholipase C-1 “PLCγ1”, with decreasing “or inhibition” in PLCγ2 “PLC beta” productions. The increasing in PLCγ1 with Deficiency in Ser amino acids will lead to deficiency in Ser phosphorylation signaling (which is main basis for Ser/Thr phosphorylation signalling which has the main function of producing proper S6K) , and decreasing in synthase activity will reflect down regulations in BTK pathways and lead to inhibition in PLCγ2 production which will reflect diabetes (inhibition in Estrogen with the production of Androgen instead of estrogen) and can reflect early Osteoarthritis “OA” prognosis dépend on the percentage of Deficiency or inhibition in basic amino acids and in basic necessary signaling pathways. The proper S6K are so necessary for reactivating both PLCγ1&2, where phospholipase Cγ2 (PLCγ2) is activated from a variety of cell surface receptors such as SyK “S6K”. As, the B cells are promoted by the function and activities of both PLCγ1&2, as the deficiency in Ser amino acids will reflect decreasing in Ser phosphorylation pathways and then decreasing in Estrogen synthesis, with increasing in Androgen synthesis which lead to decreasing in PLCs isoforms production and lead to pathogenic diabetes problem. So T2DM is strongly connected with OA disease, and both are having the same syndrome of causing their pathogenic problems, and any early step from any of those two or more similar diseases can lead to the other. Pathogenic type 2 diabetes associated with progressive beta-cell impairment due to the mutations in the production of normal insulin which due to missing of Ser phosphorylation signaling during mTOR Ser/Thr phosphorylation pathways that reflect Inhibition in the releasing of PS/T-Thymine -Kinase and PS/ T-Cytosine -kinase chains (mTORC1) which are regulating hydrophobic amino acids synthesis which can be modified by synthetase enzymes for creating the first active gamma-subunits (upon synthetase effects) that will be modified by synthase effect for Betasubunit synthesis then for alpha subunits upon phospholipase effects respectively. The previous of the releasing of PS/T-Thymine -Kinase and PS/T-Cytosine -kinase chains (mTORC1) from specifically the phosphorylation of Ser pathway is so necessary steps and mechanism for normal S6K productions, necessary for IFN-Gamma and for PLCγ1 productions, and therefore necessary for normal PLCγ2 synthesis which is necessary for B-cell activities, for T-cells modulations, for modulating anti-inflammatory steps and procedures, for thromboxane-A synthesis, and for bone growth and modulation.
https://biomedscis.com/fulltext/osteoarthritis-linked-to-diabetes-characterized-sharp-decreasing-in-ser-proline-plc%CE%B32-with-increasing-Plc%CE%B31.ID.000381.php

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