Analgesic Potential Sodium Channel SCN9A: OAJBS Publishers
Analgesic Potential Sodium Channel SCN9A by Claudia Mancilla-Simbro* in Open Access Journal of Biomedical Science (OAJBS)
Chronic
pain is one of the most complex clinical conditions to manage, it can affect
approximately 20% of the population and it has a high economic cost. In recent
years, the voltage-gated sodium channel Nav1.7 has been proposed as a possible
therapeutic target against pain, due to the evidence that certain mutations in
the gene that encodes it are associated to chronic pain or the absence of this,
depending to its nature. Several molecules have been discovered - both
synthetic and natural-with selective inhibitory potential, which may to
contribute in searching an effective treatment without side effects against
chronic pain.
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