An Old Researcher Challenges the Empirical Timing of Cy-Treatment in the Clinical Haplo-Identical Bone Marrow Transplantation Followed by High-Dose Cyclophosphamide: OAJBS Publishers

An Old Researcher Challenges the Empirical Timing of Cy-Treatment in the Clinical Haplo-Identical Bone Marrow Transplantation Followed by High-Dose Cyclophosphamide by Hisanori Mayumi* in Open Access Journal of Biomedical Science (OAJBS)

An Old Researcher Challenges the Empirical Timing of Cy-Treatment in the Clinical Haplo-Identical Bone Marrow Transplantation Followed by High-Dose Cyclophosphamide by Hisanori Mayumi* in Open Access Journal of Biomedical Science (OAJBS)

In this article, I would like to propose the correction of the empirical and inappropriate timing for cyclophosphamide (Cy) administration among the widely spread clinical haplo-identical bone marrow transplantation followed by high-dose Cy (haploBMT/ PTCy). Haploidentical bone marrow transplantation (BMT) with high-dose post-transplantation cyclophosphamide (PTCy) is now becoming a safe, effective and inexpensive treatment for patients with hematologic malignancies or hemoglobinopathies and for the tolerance induction to transplants of solid organs [1] from the same donor (2). For the method to cross the haploidentical barrier in human BMT, the Johns Hopkins protocol comprising nonmyeloablative pretreatment with fludarabine on days -6 through - 2, Cy on days -6 and -5, total body irradiation (TBI) on day -1 (=preconditioning), and BMT on day 0 followed by Cy 50mg/ kg on days 3 and 4 (=Cy-induced tolerance), and tacrolimus and mycophenolate mofetil from day 5 (=Post-immunosuppressive treatment) has been used in world-wide [2].
https://biomedscis.com/fulltext/an-old-researcher-challenges-the-empirical-timing-of-cy-treatment-in-the-clinical-haplo-identical-bone-marrow-transplantation.ID.000354.php

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