Evaluation of the Effect of Outdated Drugs for Treatment of COVID-19: OAJBS Publishers

Evaluation of the Effect of Outdated Drugs for Treatment of COVID-19 by Ali Ahmadi* in Open Access Journal of Biomedical Science (OAJBS)

Dear Editor,

Chloroquine (CQ) is considered as a drug that has been significantly motivated versus malaria and observed in 2006 that this drug has an antimicrobial potential for the mechanism and chloroquine function increases the pH of the endosomal [1]. With a higher pH of what is required for virus/cell fusion, it blocks the infection and prevents the progression of the disease. This is due to the SARS-COV-2 cellular receptor glycoproteins that are connected to their items [2]. But the hydroxy chloroquine can inhibit the stage before the cellular binding in the cell surface receptor, in a study in a study by a group of Chinese researchers and scientists about the efficiency and function of chloroquine Laboratory studies have been carried out using VERO E6 cells infected with SARSCOV-2 in polyethylene infection (MOI) 0.05, chloroquine has been very effective in reducing the virus and has an impressive effect and can infect SARS-COV- 2 block at low concentrations (effective concentration of maximum (EC50) 1.13μm and the concentration of semi-cytotoxicity (CC50) larger than 100μm). Another article showed that chloroquine could prevent the proliferation of HCOV229E in laboratory conditions in the culture of lung epithelial cells and can also be effective against the Coronavirus of the Middle East Respiratory Syndrome (Mers-Cov) in laboratory conditions. Hydroxy chloroquine (HCQ) with a very similar chemical structure with chloroquine is one of the moderating diseases of anti-rheumatic drugs used to treat many [3].
https://biomedscis.com/fulltext/evaluation-of-the-effect-of-outdated-drugs-for-treatment-of-covid-19.ID.000335.php

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