A Comparison of Capillary Versus Venous N-Terminal Prohormone Brain Natriuretic Peptide: OAJBS Publishers

A Comparison of Capillary Versus Venous N-Terminal Prohormone Brain Natriuretic Peptide by Nathaniel M Hawkins* in Open Access Journal of Biomedical Science (OAJBS)

Background: The natriuretic peptides B-type natriuretic peptide and N-terminal fragment B-type natriuretic peptide provide a relatively low-cost and accessible screening tool for heart failure. Point of care testing using finger prick capillary blood samples has been developed for BNP. We compared capillary versus venous N-terminal fragment B-type natriuretic peptide measurements using a commercially available point of care testing assay.

Methods: A cross-sectional prospective sub-analysis of a study screening 67 patients with stable chronic obstructive pulmonary disease for cardiovascular disease using N-terminal fragments of B-type natriuretic peptide was performed. Capillary and venous blood samples for each patient were analysed using a point of care testing N-terminal fragment B-type natriuretic peptide whole blood assay. Correlation between capillary and venous N-terminal fragment B-type natriuretic peptide levels was assessed. The probability of heart failure was classified based on age-stratified N-terminal fragment B-type natriuretic peptide levels.

Results: Mean capillary versus venous N-terminal fragment B-type natriuretic peptide values were similar, 236±530pg/mL vs. 237±512 (n=67), with high linear correlation (R2 = 0.96, P<0.05). Capillary testing reclassified 5 of the 39 patients (13%) designated

low probability of HF by venous testing as having intermediate values, mainly in elderly patients. No patients designated as having a moderate or high probability of having venous testing were reclassified by capillary testing.

Conclusion: There is a good correlation between N-terminal fragment B-type natriuretic peptide levels in capillary and venous samples, which suggests there may be a role for point of care testing of N-terminal fragment B-type natriuretic peptide using capillary blood samples. These findings need to be confirmed in larger populations, including more patients with heart failure.
https://biomedscis.com/fulltext/a-comparison-of-capillary-versus-venous-n-terminal-prohormone-brain-natriuretic-peptide.ID.000339.php

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