Evaluation of Some Inflammatory Biomarkers and Environmental Predictors in Children with Acute Lymphoblastic Leukemia: OAJBS Publishers

Evaluation of Some Inflammatory Biomarkers and Environmental Predictors in Children with Acute Lymphoblastic Leukemia by Mai Sabry Saleh* in Open Access Journal of Biomedical Science (OAJBS)

Acute Lymphoblastic Leukemia in children became a public health concern due to great progress in cure rates. Inflammation plays a crucial role in disease induction and progression as well as in response to treatment. The aim of the present work is to screen the inflammatory status in a cohort of pediatric patients with ALL and to define any treatment or socio-demographic variables related to its aggravation. The study included 79 cases of pediatric cancer patients diagnosed with ALL at the out-patient clinic of the National Cancer Institute in Egypt. Participants responded with their parents to complete the designed questionnaire and a blood sample was taken for assessment of cortisol, C-reactive protein, serum alpha amylase, triglycerides and total cholesterol using ELISA and colorimetric techniques as applied. The study findings showed prominent decrease in cortisol level with mean value of 119 nmol/l, outstanding rise in CRP that reached the mean value of 84 mg/L and elevated level of triglycerides (183 mg/dl). The significant decrease in cortisol was found accompanying higher compliance to treatment, increased hospitalization and early stages of treatment Total cholesterol and alpha amylase showed to be within normal ranges (185 mg/dl and 26 U/L, respectively). As a conclusion, ALL pediatric cancer patients could be suffering from chronic stress that is attributed to both the disease manifestations and treatment procedures. The increased CRP level could be a consequence of the low cortisol level and could be disease and/or treatment related.
https://biomedscis.com/fulltext/evaluation-of-some-inflammatory-biomarkers-and-environmental-predictors.ID.000312.php

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