Overexpression of PTGS2/COX-2 Gene Induces Angiogenesis, Metastasis and Invasion in TNBC In Vitro Cell Lines by Overexpressed Fzd-6 Wnt/ Ca++ Signaling Pathway: OAJBS Publishers

Overexpression of PTGS2/COX-2 Gene Induces Angiogenesis, Metastasis and Invasion in TNBC In Vitro Cell Lines by Overexpressed Fzd-6 Wnt/ Ca++ Signaling Pathway by Vikas Kumar Maurya* in Open Access Journal of Biomedical Science (OAJBS)

Cancer remains the scourge of mankind. After lung cancer, breast cancer is the second most common form of cancer. Breast cancer is the most common cancer in Indian women accounting for 27.7%with 1,62,468 newly detected cases and 87,090 deaths in 2018. Triple-negative breast cancer (TNBC) prevalence in India varies between 27 to 35% of total breast cancer [1]. TNBC refers to a subgroup of breast cancer identified by the lack of ER (Estrogen Receptor), PR (Progesterone Receptor) & HER (Human Epidermal Growth Factor Receptor). ER-/PR-/HER2- status is the main reason behind poor prognosis, failure of targeted therapy against these receptors like (Herceptin) and increased aggressiveness at an advanced stage [2]. Research paper and literature suggest that there is a lot of gene mutation, proteintruncating, receptor overexpression& dysregulation like most common BRCA1/2 amplification, p53 & Rbgene mutation, ER/ PR/HER2 overexpression, various signaling cascade inhibition, or overstimulation. Recent studies and research papers suggest that fzd-6 is particularly overexpressed in TNBC and some other cancer types like colorectal cancer and are the most studied receptors in TNBC which remains in the ON state forever [3].
https://biomedscis.com/fulltext/overexpression-of-ptgs2-cox-2-prostaglandin-endoperoxidase-synthase-2-gene-induces-angiogenesis.ID.000282.php

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