Sclerostin in Oral Tissues: Distribution, Biological Functions and Potential Therapeutic Role: OAJBS Publishers

 Sclerostin in Oral Tissues: Distribution, Biological Functions and Potential Therapeutic Role by Xianglong Han* in Open Access Journal of Biomedical Science (OAJBS)


Sclerostin is a well-known osteogenic negative regulator whose biological functions have been widely studied in bone homeostasis. Targeting sclerostin via monoclonal antibodies was shown to be a powerful strategy for bone-related diseases. Traditionally, sclerostin was known as an osteocyte-specific glycoprotein. However, in recent studies, it has been shown that in addition to osteocytes, there are other cell types in oral tissues that can produce sclerostin. Sclerostin regulates the formation of dental and periodontal structures and is also involved in various physiological and pathological events in oral tissues. Thus, sclerostin modulation has been determined as a possible treatment strategy for periodontium-related diseases. To develop the therapeutic potential of sclerostin and its antibodies in the field of dentistry, researchers must clearly understand the functions of sclerostin in oral tissues. In this review, we highlight the existing awareness of sclerostin’s functions in oral tissues; the roles it plays in dental and periodontal diseases and treatments; and the therapeutic potential of sclerostin and its antibodies for oral applications
https://biomedscis.com/fulltext/sclerostin-in-oral-tissues-distribution-biological-functions-and-potential-therapeutic-role.ID.000228.php

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