Relationship Between GDF5 +104T/C Polymorphism and the Susceptibility of Lumbar Disc Degeneration: A Meta-Analysis: OAJBS Publishers

Relationship Between GDF5 +104T/C Polymorphism and the Susceptibility of Lumbar Disc Degeneration: A Meta-Analysis by Zengwu Shao* in Open Access Journal of Biomedical Science (OAJBS)

 

Lumbar disc degeneration (LDD) is a multifactorial and chronic disease with a complex genetic background. Previous studies have reported the strong association between growth differentiation factor 5 (GDF5) +104T/C polymorphism and the risk of LDD in different ethnic populations. The aim of this study was to analyze the association between the GDF5 +104T/C polymorphism and the susceptibility of LDD by a meta-analysis. Potentially relevant studies were selected by electronic databases (PubMed, EMBASE, Web of science, the Cochrane Library Chinese National Knowledge Infrastructure) up to 10th April 2017. Summary odds ratio (OR) and 95% confidence intervals (CIs) were used to assess the strength of association between the GDF5 +104T/C polymorphism and LDD risk. Six case-control studies, including 1107 LDD cases and 4353 controls, were included. The combined results showed that GDF5 +104T/C polymorphism was significantly associated with increased susceptibility to LDD at the allele level (T vs. C: OR = 1.52, 95%CI = 1.21-1.90) and genotype level (TT vs. CC: OR = 2.43, 95%CI = 1.81-3.25; TC vs. CC: OR = 1.84, 95%CI = 1.37-2.47; TT+TC vs. CC: OR = 2.14, 95%CI = 1.61-2.84; TT vs. TC+CC: OR = 1.42, 95%CI = 1.01-1.99) in the overall population. After stratified by ethnicity, we found a strong significant association (OR = 1.80 to 3.70, all P <0.05) in Asian population and weaker associations (OR =1.20 to 1.64, all P <0.05) in Caucasian population. This meta-analysis suggests an increased risk of GDF5 +104T/C polymorphism against intervertebral disc degeneration among populations especially in Asians.

https://biomedscis.com/fulltext/relationship-between-gdf5-104t-c-polymorphism-and-the-susceptibility-of-lumbar-disc-degeneration-a-meta-analysis.ID.000231.php

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