Expression, Regulation and Functions of MicroRNAs in Autoimmune Hepatitis: OAJBS Publishers

Expression, Regulation and Functions of MicroRNAs in Autoimmune Hepatitis by Xiaoyan Chi* in Open Access Journal of Biomedical Science (OAJBS)

Autoimmune hepatitis (AIH) is a rare severe liver disorder, which affects both children and adults worldwide. Studies have shown that AIH may result from the abnormal body’s immune system, which attacks own liver, and causes inflammation and liver damage. However, the exact cause of AIH is unclear. Recent studies have demonstrated that epigenetic regulations including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), DNA methylation and histone modifications play an important role in disease pathogenesis. In this review, expression, regulation and functions of miRNAs in AIH were discussed. It has been shown that specific miRNAs such as miR-21, miR-29a, miR-122, miR-155, miR-221 and miR-223 are involved in the control of cytokine production and regulation of proliferation, apoptosis and functions of liver-infiltrating mononuclear cells, which may be responsible for AIH development. The results may provide insights into the basic mechanisms underlying the dysregulation of miRNAs in AIH that could lead to development of strategies for epigenetic and pharmacologic intervention. Thus, such studies may lead to establishing a rapid diagnostic and prognostic method for early detection and effective treatment of AIH to prevent liver cancer. However, the underlying mechanisms in the expression, regulations and functions of miRNAs in AIH have not been understood and further studies will be necessary.
https://biomedscis.com/fulltext/expression-regulation-and-functions-of-micrornas-in-autoimmune-hepatitis.ID.000234.php

 To Know More About Open Access Journal of Biomedical Science Please Visit: Biomedscis
Are Click on:  https://Biomedscis.Com/

Comments

Post a Comment

Popular posts from this blog

Facile Synthesis of Chitosan Nanoparticle with Different Features and Histopathological Ultrastructural Study on The Effect of Its Bio-complex with Bovine Serum Albumin: OAJBS Publishers

Image
Facile Synthesis of Chitosan Nanoparticle with Different Features and Histopathological Ultrastructural Study on The Effect of Its Bio-complex with Bovine Serum Albumin in Mice Liver by Maged El-Kemary* in Open Access Journal of Biomedical Science (OAJBS)   We have synthesized chitosan nanoparticles (CS-NPs) with different characteristics using ionic gelation method. Results showed that the synthesized CS-NPs with different concentrations of trisodium polyphosphate (TPP) are irregular – spherical shaped with narrow size distribution and high stability. The microporous chitosan was also synthesized with new features characterized with different techniques as SEM, EDX, FTIR and BET. The synthesized microporous chitosan has a surface area and pore volume of 245.571m 2 /g and 0.155cm 3 /g respectively. Its microporous surface is functionalized with carboxyl and amine groups. Histopathological and ultrastructural studies of mice liver were performed using optical and scanning electron m...
Read more

Carlos Gravato | Biomedscis Editor

Image
Biomedscis  Honorable Editors Name: Carlos Gravato Department: Department of Science University: University of Lisbon Country: Portugal Completed PhD in Biology (2002). Working as Assistant Professor in FCUL and CESAM, University of Lisbon, Portugal. Biomarkers; Animal Physiology; Cell Biology; Neurobiology; Animal Behavior; Ecotoxicology; Adaptation Biology To Know More About Open Access Journal of Biomedical Science   Please Visit:  Biomedscis Are Click On:   Https://Biomedscis.com
Read more

Review on Analysis of Breast Tumor with Methods of Treatment: OAJBS Publishers

Image
Review on Analysis of Breast Tumor with Methods of Treatment by Nagham Mahmood Aljamali* in Open Access Journal of Biomedical Science (OAJBS) Breast malignance is the greatest public in ladies, with a high incidence in North America and Eastern Europe, medium in Southern Europe and the Middle East and low in the Far East. Breast malignance is the second most common malignance in the world after lung malignance, and since it happens a lot, the doctors asked the women to examine themselves by themselves, in order to discover the signs of the disease early before it spreads. It is possible that this disease can be treated after being diagnosed by a specialized doctor and determining the type of tumor in the breast, and the surgeon removes the breast completely and starts chemotherapy about 6 doses, then radiotherapy, how many sessions will be determined by the doctor, and then hormonal therapy, a medicine called Tamoxafin or any medicine determined by the doctor, and it is possible. This ...
Read more