Post-Transplant Cyclophosphamide in Hematopoietic Stem Cell Transplantation for Langerhans Cell Histiocytosis: OAJBS Publishers

Post-Transplant Cyclophosphamide in Hematopoietic Stem Cell Transplantation for Langerhans Cell Histiocytosis by Rong Liu in Open Access Journal of Biomedical Science


Hematopoietic stem cell transplantation (HSCT) has the potential to cure refractory multisystem Langerhans cell histiocytosis (MS-LCH). However, a post-transplant cyclophosphamide (PTCy) regimen has never been applied for refractory MS-LCH. The objective of this article is to report the successful use of PTCy after reduced-intensity conditioning haploid HSCT in a 22-monthold girl with refractory MS-LCH and hemophagocytic lymphohistiocytosis (HLH). Her clinical symptoms were recurrent fever, polydipsia, diuresis, rash, and hepatosplenomegaly. She failed to respond to chemotherapy but was finally cured by haploid HSCT with PTCy regime. This case enriched our knowledge of the management of graft-versus-host disease prophylaxis in LCH patients, which has not been reported before.
https://biomedscis.com/fulltext/post-transplant-cyclophosphamide-in-hematopoietic-stem-cell-transplantation-for-langerhans-cell-histiocytosis.ID.000214.php

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