The Extraction of DAM Enhance Antioxidant Capacity of Mice In-vivo: OAJBS Publishers

The Extraction of DAM Enhance Antioxidant Capacity of Mice In-vivo by Jingxue Wang in Open Access Journal of Biomedical Science

A mixture of functional complex extraction from Dendrobium Candidum and other Chinese herbs enhances. Plant polysaccharides are one of the most bioactive substances present in plants. Due to the broad-spectrum therapeutic properties and biosafety, natural polysaccharides isolated from plants have recently been attracted attention by more and more researcher. The present study was designed to investigate the possible anti-aging and intestinal flora effect of Dendrobium Candidum and Astragalus mongholicus (DAM) on the aging model mouse. In the experiment, 48 aging female Institute of Cancer Research mice (ICR mice) were randomly divided into the control group and low-mediumhigh dose groups (200,400,800 mg/kg/day). The results showed that gradually recovered the body weight, the activity of daily living, and organ indices of mice. To be specific, DAM obviously improved the activities of antioxidant enzymes in liver and spleen of ICR mice, including catalase (CAT) and superoxide dismutase (SOD), as well as decreased malondialdehyde (MDA) levels when compared with those in control group mice. Furthermore, the DAM can improve the weight-bearing swimming time of the mice, increase the tolerance of the aging body, shorten the mouse’s adaptation to the labyrinth, increase the number of individuals entering the open end and prolong their stay time on the basis of not affecting the mobility of the mice and has a certain anti-anxiety effects. The abundance of pathogenic bacteria of Bilophila and Oceanobacillus in the intestinal tract of aging mice was higher than that of the compound compound intragaemia group. The abundance of intestinal probiotics such as Akkermansia, Bacteroides and Bifidobacterium in the low-dose group was higher than that of the aging control group, and also higher than that of the medium-dose and high-dose groups. These results demonstrate that DAM preparation had an effect on improving the antioxidant capacity of organs in aging mice, delaying the aging of organs, and enhancing the resistance of aging individuals.
https://biomedscis.com/fulltext/the-extraction-of-dam-enhance-antioxidant-capacity-of-mice-in-vivo.ID.000159.php

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