Hemostatic Effect of Platelet Rich Fibrin Versus Tranexamic Acid After Tooth Extraction in Patients Under Anticoagulant Therapy: OAJBS Publishers

Hemostatic Effect of Platelet Rich Fibrin Versus Tranexamic Acid After Tooth Extraction in Patients Under Anticoagulant Therapy by Salman Shams in Open Access Journal of Biomedical Science

Objective: The compare the efficacy achieved by platelet rich fibrin versus tranexamic acid dressing placed in bony socket after tooth extraction in patients who are taking anticoagulant drugs. Study design: Experimental study. Place and Duration of study: Department of Oral & Maxillofacial Surgery, Liaquat University of Medical & Health Sciences, Jamshoro / Hyderabad, from 13th April 2017 to 12th April 2018. Methodology: All 84 patients were divided into 2 equal groups by lottery method, group-A and group-B. In group A, after the tooth extraction, socket was filled with dressing of 4.85% tranexamic acid (TXA). In group B, a platelet rich fibrin (PRF) extracted from the autologous blood and stabilized in the post extraction socket with sutures. Post-extraction site was monitored for one week to assess and record the bleeding from tooth socket on 1st two hours before dismissal, 2nd, 3rd, 5th and 7th days postoperatively. In case of no bleeding from socket on 7th postoperative day, positive efficacy was considered. Results: There were 84 patients in total. Males were 50/84 (59.5%) while females were 34/84 (40.5%). Efficacy in Group A (Platelet rich fibrin) was found in 41/42 (97.61%) patients while in Group B (Tranexamic acid) it was found in 39/42 (92.86%) patients. When the Chi. square test was applied to see effects between efficacies in both groups, it was found that there were no significant association between both groups having p-value 0.306. After the stratification of gender, and duration of anticoagulant use, the efficacy was not found significant among both groups.
https://biomedscis.com/fulltext/hemostatic-effect-of-platelet-rich-fibrin-versus-tranexamic-acid-after-tooth-extraction-in-patients-under-anticoagulant-therapy.ID.000187.php

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