Different Types of Surface Modification used for Improving the Adhesion and Interactions of Skin Cells: OAJBS Publishers

Different Types of Surface Modification used for Improving the Adhesion and Interactions of Skin Cells by Anna Sobiepanek in Open Access Journal of Biomedical Science

Mammalian cells in the traditional 2D culture lack the complexity of 3D tissue architecture as well as the cell-cell or cell-extracellular matrix (ECM) interactions, which are present in the body. Still they are one of the most accessible and popular models used in biomedical research. Simultaneously, the understanding of various cell interactions in the body brings a valuable source of knowledge for the continuous improvement of several research areas including new biocompatible materials, tissue regeneration attempts, devices of the Lab-on-a-Chip type or cell-based biosensors for different applications. In order to meet the needs of cell culture improvement and a better understanding of the physiological cell interactions, within years different cellular surface modifications with biomolecules or chemicals have been introduced. These modifications play an important role in the regulation of several processes in cells such as adhesion, proliferation, differentiation, interaction and signalling. In this review, we have described the typical surface modifications used for the cell culture of different skin cells with a brief specification of the mechanism of cell adhesion. The skin cells like keratinocytes, fibroblasts, melanocytes, but also cancer cells (especially melanoma cells) are the perfect models for studying adhesion mechanisms in vitro due to their mutual physiological interaction in the skin tissue.
https://biomedscis.com/fulltext/different-types-of-surface-modification-used-for-improving-the-adhesion-and-interactions-of-skin-cells.ID.000161.php

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