Endogenous Adult-Derived Telomerase-Positive Stem Cells: OAJBS Publishers

Endogenous Adult-Derived Telomerase-Positive Stem Cells by Henry E Young* in Open Access Journal of Biomedical Science (OAJBS)

 

 

 

Discovered in 1975 Located in the connective tissues throughout the body, ~ 10% of all stem cells in the body Found in 16 different species: terrestrial salamander, Komodo dragon, chicken, waddle crane, mouse, rat, rabbit, cat, dog, sheep, goat, pig, cow, speckled bear, horse, and human They are the natural healing cells of the body, they do NOT decrease in number with increasing age of the individual Cloned from single cells by repetitive serial dilution clonogenic analysis and then extensively characterized Consist of the following. Totipotent stem cells-form any cell type in the body, including spermatogonia and oogonia. Pluripotent stem cells-form any cell type in the body, except spermatogonia and oogonia Ectodermal stem cells-will only form cells of the ectodermal embryonic lineage• Mesodermal stem cells-will only form cells of the mesodermal embryonic lineage. Endodermal stem cells- will only form cells of the endodermal embryonic lineage Utilized for treatments. Will NOT form teratomas (cancerous cells) in situ or ex vivo. Normally quiescent, unless activated. Inside the body, activation requires about 2 weeks Outside the body, activation takes 2 hours. Can be expanded to significant numbers inside the body (in situ) using combinatorial nutraceuticals and outside the body (ex vivo) in culture using proprietary culture media: Essentially unlimited proliferation potential. Transplanted either as autologous (self) and/or allogeneic (donor)Donor needs to be matched for gender, ABO blood group (or O-negative), infectious disease-free and deleterious genetic mutation-free.
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