Clinical Assessment of Anesthesia Caused by Combinational Protocol of Acepromazine-Fentanyl- Ketamine in Dogs: OAJBS Publishers
Clinical Assessment of
Anesthesia Caused by Combinational Protocol of
Acepromazine-Fentanyl- Ketamine in Dogs by Mahmoud Tohidi Moghadam* in Open
Access Journal of Biomedical Science (OAJBS)
The purpose of the present study is the clinical
assessment of anesthesia by adding fentanyl to ketamine and acepromazine in
dogs and the clinical assessment of dogs during this anesthesia. In this study,
12 mixed-breed dogs, that weigh 20 -30 kg and are 2-3 years old, were selected
and divided into two test and control groups. Anesthetizing of the test group
is done by intramuscular injection of 0.2 mg of kg acepromazine and intravenous
injection of 0.1 mg kg of fentanyl and intramuscular injection of 20 mg kg of ketamine
after 10 minutes. Anesthetizing of the control group is done by intramuscular
injection of 0.2 mg kg of acepromazine and intramuscular injection of 20 mg kg
of ketamine after 10 minutes. One hour after anesthetizing both test and
control groups, parameters such as: heart rate, respiratory rate, rectal temperature
and clinical symptoms such as duration of analgesia and duration of anesthesia
were assessed in 10-minute-interval periods. T independent test, ANOVA, and
Tukey Post Hoc were used for the statistical analysis of the data. As the
results show, the dogs’ heart rate was increased in both groups without any
significant difference (P> 0.05); however, the respiration rate in the
experimental group was reduced significantly (P <0.05). It has to be
mentioned that two dogs suffered apnea during the injection of fentanyl and
were returned to normal respiration after 2-3 minutes by CPR. A significant
different (p<0.05) was observed in rectal temperature of the experiment
group between first 10-minte-interval-period and last 10-minte-interval-period;
moreover, a significant increase (P<0.05) was observed in the duration of
analgesia and anesthesia. In this study, it was demonstrated that adding 0.1 mg
kg of fentanyl to acepromazine and ketamine has a significant influence on the
reduction of respiratory rate and the increase in the duration of analgesia and
anesthesia; however, this addition does not have any significant influence on
clinical symptoms of the dogs. Based on the results of this study, it can be
suggested that this combination can be used as beneficial in the reduction of
respiratory rate and the increase in the duration of analgesia and anesthesia.
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