The Proteasomal Subunits: Potential Therapeutic Targets for Cancer: OAJBS Publishers
The
Proteasomal Subunits: Potential Therapeutic Targets for Cancer by Abdulfattah
Salah Fararjeh* in Open Access Journal of
Biomedical Science (OAJBS)
Without doubt, we can understand that cancer such
as breast cancer is considered as a heterogeneous disease. It consists of
several molecular subtypes and each subtype has a unique signaling pathways
with a distinct growth and proliferation stimulatory. Throughout the last few
decades, the information about the cellular process and signaling pathways that
involved in cancer become clearer. These cellular processes and signaling
pathways have been reported to affect the survival, proliferation, migration,
invasion and apoptosis of the cancer cells [1-4]. Indeed, these signaling
pathways frequently have cross talk between each other either direct or
indirect to maintain breast cancer cell signaling on which able to respond to
the external stimulators. Most of the researcher nowadays focusing on targeting
these signaling pathways which can disrupt the internal cross talk signals in
the cancer cell. However, another recent field that the scientist working on is
the proteasome. The ubiquitin proteasomal system (UPS) is an important
regulator for cell growth and cellular apoptosis. In cancer, the function and
activities of proteasome are altered. For example, in apoptosis, several
signaling pathways are included from releasing cytochrome C, activation Apaf-I
containing activation of caspases apoptosome complex [5], all of these process
by mitochondria. UPS system has an important role in regulating caspase and
some of the apoptosis marker like BCL-2. For that, targeting proteasome could
exert anticancer effect by inducing apoptosis and may also exert antitumor
effect in-vivo.
Are Click On:
https://Biomedscis.Com/
Comments
Post a Comment